منابع مشابه
Transcriptional Regulation of Axon Pathfinding
different species and neuron types. Some are candi-† Neuron dates for being direct regulators of the molecules that Cell Press confer pathfinding specificity. In each system dis-Cambridge, Massachusetts 02138 cussed, the projection phenotypes of the neurons involved had been described previously so that alterations in pathfinding were easily recognized. Neuronal differentiation has been postula...
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We have isolated mutants in the zebrafish Danio rerio that have defects in axonal connectivity between the retina and tectum. 5-day-old fish larvae were screened by labeling retinal ganglion cells with DiI and DiO and observing their axonal projections to and on the tectum. 82 mutations, representing 13 complementation groups and 6 single allele loci, were found that have defects in retinal gan...
متن کاملGlia, neurons, and axon pathfinding during optic chiasm development.
The importance of vision in the behavior of animals, from invertebrates to primates, has led to a good deal of interest in how projection neurons in the retina make specific connections with targets in the brain. Recent research has focused on the cellular interactions occurring between retinal ganglion cell (RGC) axons and specific glial and neuronal populations in the embryonic brain during f...
متن کاملGanglion cell axon pathfinding in the retina and optic nerve.
The eye is a highly specialized structure that gathers and converts light information into neuronal signals. These signals are relayed along axons of retinal ganglion cells (RGCs) to visual centers in the brain for processing. In this review, we discuss the pathfinding tasks RGC axons face during development and the molecular mechanisms known to be involved. The data at hand support the presenc...
متن کاملZebrafish foxP2 Zinc Finger Nuclease Mutant Has Normal Axon Pathfinding
foxP2, a forkhead-domain transcription factor, is critical for speech and language development in humans, but its role in the establishment of CNS connectivity is unclear. While in vitro studies have identified axon guidance molecules as targets of foxP2 regulation, and cell culture assays suggest a role for foxP2 in neurite outgrowth, in vivo studies have been lacking regarding a role for foxP...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2016
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2016.144